You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air

https://travisphgy109.quillnesty.com/posts/why-san-diego-s-climate-makes-roof-rat-proofing-a-year-round-job-4

You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air and raise the risk of exposure to rodent-borne diseases.